Having set up the Vbar, the Ikon, Skookum and the 3GX, I would say that they are all easy, as well as difficult to set up.
The basic thing is how precise are you willing to do the basic mechanical set up on your heli. That is where the difficult part of the setup comes into play, and it is really critical if you want to get a good flying heli.
The 3GX is the least tolerant of a poor mechanical setup, and the Vbar is the most. The Ikon falls into the middle (but maybe leans towards the 3GX)
Like Ronald said, a lot is going to depend on what method you use to set up the FBL controller. I like the computer based setups, but they force you to have a laptop with you in the field to make any changes. I don't have any experience with the BeastX, but I have read people think it is the easiest to setup. The reason my preference runs to a computer based setup is that you don't have to rely on LED pinpoints of lights to tell you where you are in the programming. With the computer based setups, you can take as much time as you need, and reference any additional manuals/help that you need while you are looking at the screen.
Also, for sub-menus, you don't have to remember how you got there in the first place (by pressing a set button "X" number of times, etc). Most everyone today is some sort of functional with a computer, and so you should not have any real issues using a computer based setup.
Goblin 700, Trex 700DFC, Gaui X7, Logo 690SX, Logo 600SX; Trex 470 Trex 500
Amain Team Rep